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Purified anti-human CD192 (CCR2) Recombinant Antibody

Pricing & Availability
Clone
K036C2.RecM1 (See other available formats)
Regulatory Status
RUO
Other Names
CKR2, CCR2A, CCR2B, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
K036C2RecM1_PURE_CD192_FC_070125-2
Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) APC and purified anti-human CD192 (CCR2) recombinant (clone K036C2.RecM1) (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
  • K036C2RecM1_PURE_CD192_FC_070125-2
    Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) APC and purified anti-human CD192 (CCR2) recombinant (clone K036C2.RecM1) (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
Cat # Size Price Quantity Save
357223 100 µg ¥51,700
Description

CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Chemokine receptor, GPCR, seven transmembrane receptor
Distribution

Monocytes, macrophages, immature dendritic cells, memory T cells

Function
Induces monocyte adhesion to endothelial cells and chemotaxis
Ligand/Receptor
CCL2 (MCP-1), CCL7 (MCP-3), CCL8 (MCP-2), CCL13 (MCP-4), CCL16 (HCC4)
Cell Type
Dendritic cells, Macrophages, Monocytes, T cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References
  1. Wong LM, et al. 1997. J. Biol. Chem. 272:1038.
  2. Papadopoulou C, et al. 2008. Cytokine. 43:181.
  3. Barlic J, et al. 2007. J. Leukoc. Biol. 82:226.
  4. Gu L, et al. 1998. Mol. Cell. 2:275.
  5. Volpe S, et al. 2012. PLoS One. 7:e37208.
Gene ID
729230 View all products for this Gene ID
UniProt
View information about CD192 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 07/01/2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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