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Purified anti-ARC/ARG3.1 Antibody

Pricing & Availability
Clone
W23239B (See other available formats)
Regulatory Status
RUO
Other Names
Activity-Regulated Cytoskeleton-Associated Protein, Activity-Regulated Gene3.1 Protein Homolog, hArc, KIAA0278
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
W23239B_PURE_ARC-ARG31_Antibody_1_110525
Whole cell extracts (15 μg total protein per lane) from indicated cell lines were resolved by 4-12% Bis-Tris gel electrophoresis, transferred to a PVDF membrane, and probed with Purified anti-ARC/ARG3.1 antibody (clone W23239B). Proteins were visualized by chemiluminescence detection using HRP Goat anti-rat IgG (Cat. No. 405405). Direct-Blot™ HRP anti-GAPDH (Cat. No. 607903) was used as a loading control. Western-Ready™ ECL Substrate Premium Kit (Cat. No. 426319) was used as a detection agent. Lane M: Molecular weight marker
  • W23239B_PURE_ARC-ARG31_Antibody_1_110525
    Whole cell extracts (15 μg total protein per lane) from indicated cell lines were resolved by 4-12% Bis-Tris gel electrophoresis, transferred to a PVDF membrane, and probed with Purified anti-ARC/ARG3.1 antibody (clone W23239B). Proteins were visualized by chemiluminescence detection using HRP Goat anti-rat IgG (Cat. No. 405405). Direct-Blot™ HRP anti-GAPDH (Cat. No. 607903) was used as a loading control. Western-Ready™ ECL Substrate Premium Kit (Cat. No. 426319) was used as a detection agent. Lane M: Molecular weight marker
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649403 25 µg 120€
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649404 100 µg 280€
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Description

The ARC/ARG3.1 protein, also known as activity-regulated cytoskeleton-associated protein, is a critical regulator of synaptic plasticity and cognitive function. It is an immediate early gene whose transcription is rapidly induced by neuronal activity, particularly through NMDA receptor activation and signaling pathways involving CREB, MEF2, and SRF. ARC mRNA is transported to dendrites and locally translated at synapses, where the protein modulates synaptic strength by regulating AMPA receptor trafficking promoting endocytosis during long-term depression (LTD) and stabilizing actin cytoskeleton during long-term potentiation (LTP). Dysregulation of ARC expression or function has been implicated in several neurological disorders, including Alzheimer's disease, schizophrenia, epilepsy, autism spectrum disorders, and Fragile X syndrome. 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant fragment of human ARC/ARG3.1 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
The ARC/ARG3.1 protein in humans consists of 396 amino acids and has a molecular weight of approximately 45.3 kDa
Distribution

Primarily localized in vesicles and microtubules. In neurons, it is found in dendrites, axons, and synapses.

Interaction
Endophilin and Dynamin, PICK1 (Protein Interacting with C Kinase 1), PABPN1 (Polyadenylate-binding nuclear protein 1), PSF (Polypyrimidine tract-binding protein-associated splicing factor), PSEN1
Cell Type
Dendritic cells, Neurons
Biology Area
Cell Biology, Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
Molecular Family
Adaptor Proteins, Cytoskeletal Proteins, Neurotransmitter Receptor Trafficking/Endocytosis
Antigen References
  1. Zhang H, et al. 2021. Eur J Neurosci. 54(8):6696
  2. Hedde PN, et al. 2021. Front Mol Biosci. 8:630625
  3. Wall MJ, et al. 2018. Semin Cell Dev Biol. 77:17
Gene ID
23237 View all products for this Gene ID
UniProt
View information about ARC on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/05/2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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