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PE anti-human OSMR Antibody

Pricing & Availability
Clone
S22005D (See other available formats)
Regulatory Status
RUO
Other Names
IL-31 receptor subunit beta, oncostatin-M specific receptor beta subunit.
Isotype
Mouse IgG1, κ
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Product Citations
publications
S22005D_PE_OSMR_FC_073025
U-87 MG cells (human glioblastoma cell line) were stained with anti-human OSMR (clone S22005D) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • S22005D_PE_OSMR_FC_073025
    U-87 MG cells (human glioblastoma cell line) were stained with anti-human OSMR (clone S22005D) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
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321810 25 tests 137€
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321811 100 tests 305€
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Description

Oncostatin M receptor (OSMR), also known as IL-31 receptor subunit beta, is a member of the IL-6 receptor family. It is expressed in bone marrow, endothelium, liver, lung and skin tissues. OSMR forms the type II OSM receptor complex when paired with interleukin 6 signal transducer (gp130) and forms the IL-31 receptor when complexed with interleukin 31 receptor A (IL31RA). The binding of OSM to either of these receptors triggers activation of the JAK-STAT signaling pathway.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human OSMR protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone S22005D does not affect the binding of clone S22005H on target cells.

Antigen Details

Structure
Transmembrane immunoglobulin-like glycoprotein, 130 kD
Distribution

Hepatocytes, mesothelial cells, glial cells and epithelial cells

Function
Ligand binding, signal transduction
Interaction
gp130, IL-31RA
Ligand/Receptor
IL-31, OSM
Cell Type
Epithelial cells, Macrophages, Mesenchymal cells, Monocytes
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. Mosley B, et al. 1996. J Biol Chem. 271:32635.
  2. Auguste P, et al. 1997. J Biol Chem. 272:15760.
  3. Hermanns HM, et al. 1999. J. Immunol. 163:6651.
Gene ID
9180 View all products for this Gene ID
UniProt
View information about OSMR on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 07/30/2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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