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PE anti-human HVCN1 Antibody

Pricing & Availability
Clone
W23068A (See other available formats)
Regulatory Status
RUO
Other Names
Hydrogen voltage gated channel 1, HV1, VSOP, voltage sensor domain-only protein
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W23068A_PE_HVCN1_Antibody_1_101525
Human peripheral blood mononuclear cells were fixed, permeabilized and intracellularly stained with anti-human CD19 (clone HIB19) Brilliant Violet 421™ and anti-human HVCN1 (clone W23068A) PE (left) or rat IgG2a, κ PE isotype control (right). Data shown is gated on the lymphocyte population.
  • W23068A_PE_HVCN1_Antibody_1_101525
    Human peripheral blood mononuclear cells were fixed, permeabilized and intracellularly stained with anti-human CD19 (clone HIB19) Brilliant Violet 421™ and anti-human HVCN1 (clone W23068A) PE (left) or rat IgG2a, κ PE isotype control (right). Data shown is gated on the lymphocyte population.
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377109 25 tests 180€
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377110 100 tests 324€
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Description

Hydrogen voltage-gated channel 1 (HVCN1) is a voltage gated, proton-selective channel expressed in immune cells, spermatozoa, and upper respiratory tract epithelial cells. HVCN1 mediates proton conductance to prevent membrane depolarization and cytoplasmic acidification. In phagocytes, it is required for the oxidative burst that underlies microbial killing, and in B cells, it facilitates antibody production. HVCN1 can also regulate functions in other cells including spermatozoa.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant human HVCN1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool).
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details

Structure
Transmembrane protein with four helix transmembrane domain and a coiled coil c-terminal cytoplasmic domain
Distribution

Immune cells (B-cells, Neutrophils, Monocytes), spermatozoa, upper respiratory epithelium

Function
Proton transporter
Molecular Family
Ion Channels
Antigen References
  1. Zhu X, et al. 2013. BMC Immunol. 14:24.
  2. Hondares E, et al. 2014. Proc. Natl. Acad. Sci. 111:50. 
  3. Okochi Y, et al. 2021. Int. J. Mol. Sci. 22:2620.
  4. Wang Y, et al. 2011. Biochem. Biophys. Res. Commun. 2: 412.
  5. Cherny VV, et al. 2015. J. Gen. Physiol. 5: 146.
  6. De Coursey TE. 2015. Biochemistry. 54: 21.
Gene ID
84329 View all products for this Gene ID
UniProt
View information about HVCN1 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 10/15/2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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