Ultra-LEAF™ Purified anti-mouse CD7 Antibody, CD7, S23010C

Pricing & Availability

Clone: S23010C (See other available formats)
Regulatory Status: RUO
Other Names: CD7 antigen, CD7 molecule, GP40, TP41, T-Cell Leukemia Antigen, LEU-9, Tp40
Isotype: Rat IgG1, κ
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Product Citations: publications

S23010C_ULEAF_CD7_Antibody_012726 — Recombinant Mouse CD7 (Cat. No. 588404; black circles) binds to immobilized Recombinant Mouse SECTM1a-Fc Chimera (Cat. No. 799404). Ultra-LEAF™ Purified anti-mouse CD7 (clone S23010C, purple squares) inhibits the binding in a dose-response manner, whereas Ultra-LEAF™ Purified Rat IgG1, κ Isotype Control (Cat. No. 400431, gray triangles) has no inhibitory effect. This antibody blocks the binding of 0.1 µg/mL Recombinant Mouse CD7 to 5.0 µg/mL of immobilized Recombinant Mouse SECTM1a-Fc Chimera. The ND₅₀ range to observe this effect is: 0.25 – 2.5 µg/mL.

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648729

100 µg

275 CHF

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648730

1 mg

685 CHF

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Description

CD7, a member of the Ig superfamily, is a 40-kDa type I transmembrane glycoprotein containing a single Ig domain. It is expressed in T cell precursors, mature T cells, natural killer (NK) cells, myeloid precursors, plasmacytoid dendritic cells (DCs), pre-B cells, and various leukemic cells. Mouse CD7 consists of 210 amino acids, with the mature protein comprising residues 24-210 and featuring a 127-amino acid extracellular domain. Like CD28, the intracellular domain contains a YEEM motif that activates the PI3K signaling pathway. Treatment anti-CD7, in conjunction with anti-CD3 or PMA, demonstrates that CD7 is mitogenic for human T cells and induces IL-2 production.
Additionally, a CD7-, CD4+ subpopulation of memory T cells has been shown to accumulate in skin lesions associated with chronic inflammatory conditions. CD7 is overexpressed in T lymphocytes infiltrating classical Hodgkin lymphoma and is highly expressed in T cell acute lymphoblastic leukemia (T-ALL). Consequently, CD7 has become a target for novel therapeutic approaches, such as chimeric antigen receptor (CAR) T cell therapy.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse CD7-transfected cells
Formulation: 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
Preparation: The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration: The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Application: Neut - Quality tested
Recommended Usage: Each lot of this antibody is tested by neutralizing the binding of 0.1 μg/mL recombinant mouse CD7 (Cat. No. 588404) to 5.0 µg/mL immobilized recombinant mouse SECTM1a-Fc chimera (Cat. No. 799404). ND₅₀ range: 0.25 – 2.5 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure: Monomer
Distribution: T-lineage cells (such as T cells and thymocytes), natural killer (NK) cells, lymphoid progenitor cells, lung microvascular endothelial cells. Highly expressed in T-cell malignancies (T-ALL and lymphoblastic lymphomas), acute myeloid leukemia, head and neck squamous cell carcinoma
Function: Regulation of T cell persistence, T cell infiltration, co-stimulation and cytokine production, cell adhesion modulation.
Interaction: Terminally exhausted CD8+ T cells, T cells, NK cells, myeloid cells, thymocytes, mature B cells
Ligand/Receptor: SECTM1 (secreted and transmembrane) proteins
Cell Type: Dendritic cells, Macrophages, Monocytes, NK cells, T cells, Thymocytes, Tregs
Biology Area: Adaptive Immunity, Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability, Costimulatory Molecules, Immuno-Oncology
Molecular Family: CD Molecules
Antigen References: Hyslop S, et al. 2025. Cell Rep. 44:116316.

Visser N, et al. 2025. Mol Ther Oncol. 33:200988.

Wei W, et al. 2023. Blood Adv. 7:2941-2951.

Sheng B, et al. 2023. Heliyon. 9:e16961.

Kim MY, et al. 2021. JCI Insight. 6:e149819.
Gene ID: 12516 View all products for this Gene ID
UniProt: View information about CD7 on UniProt.org

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Related FAQs

Do you guarantee that your antibodies are totally pathogen free?: BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.
Does BioLegend test each Ultra-LEAF™ antibody by functional assay?: No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.
Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?: No, BioLegend does not test for pathogens in-house unless otherwise indicated. However, we can recommend an outside vendor to perform this testing as needed.
Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?: We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.

Other Formats

View All CD7 Reagents Request Custom Conjugation

Description	Clone	Applications
Ultra-LEAF™ Purified anti-mouse CD7	S23010C	Neut

Certificate of Analysis

Go To Top Version: 1 Revision Date: 01.27.2026

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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