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APC anti-mouse CD45 Antibody

Pricing & Availability
Clone
30-F11 (See other available formats)
Regulatory Status
RUO
Other Names
T200, Ly-5, LCA
Isotype
Rat IgG2b, κ
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Product Citations
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30-F11_APC_090507
C57BL/6 mouse splenocytes stained with 30-F11 APC
  • 30-F11_APC_090507
    C57BL/6 mouse splenocytes stained with 30-F11 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
103111 25 µg $33
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103112 100 µg $94
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Description

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from variable splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse thymus or spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone 30-F11 reacts with all isoforms and both CD45.1 and CD45.2 alloantigens of CD45.

Additional reported applications (for relevant formats) include: immunoprecipitation3, complement-dependent cytotoxicity1,5, immunohistochemistry (acetone-fixed frozen sections, zinc-fixed paraffin-embedded sections and formalin-fixed paraffin-embedded sections)4,6, Western blotting7, and spatial biology (IBEX)10,11. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103163 and 103164).

Application References

(PubMed link indicates BioLegend citation)
  1. Podd BS, et al. 2006. J. Immunol. 176:6532. (FC, CMCD) PubMed
  2. Haynes NM, et al. 2007. J. Immunol. 179:5099. (FC)
  3. Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IP)
  4. Simon DI, et al. 2000. J. Clin. Invest. 105:293. (IHC)
  5. Seaman WE. 1983. J. Immunol. 130:1713. (CMCD)
  6. Cornet A, et al. 2001. P. Natl. Acad. Sci. USA 98:13306. (IHC)
  7. Tsuboi S and Fukuda M. 1998. J. Biol. Chem. 273:30680. (WB) PubMed
  8. Liu F, et al. 2012. Blood. 119:3295. PubMed
  9. Pelletier AN, et al. 2012. J. Immunol. 188:5561. PubMed
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Witherel CE, et al. 2021. Biomaterials. 269:120667. PubMed
  2. Kozuki S, et al. 2022. Genes Cells. 27:192. PubMed
  3. Cautivo KM, et al. 2022. Immunity. 55:254. PubMed
  4. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  5. Lloyd-Lewis B, et al. 2022. Cell Rep. 38:110461. PubMed
  6. Yang Y, et al. 2022. FEBS J. 289:5279. PubMed
  7. MacLean AJ, et al. 2022. Immunity. 55:718. PubMed
  8. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  9. Van Deren DA, et al. 2022. Development. 149: . PubMed
  10. Lee R, et al. 2022. Cancer Discov. 12:1702. PubMed
  11. Jiang W, et al. 2022. FASEB J. 36:e22294. PubMed
  12. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  13. Wu TJ, et al. 2022. Cell Mol Life Sci. 79:348. PubMed
  14. Malhi H, et al. 2022. Cell Rep Med. 3:100658. PubMed
  15. Campisi L, et al. 2022. Nature. 606:945. PubMed
  16. Ma Z, et al. 2022. Theranostics. 12:4965. PubMed
  17. Richards M, et al. 2022. Elife. 11: . PubMed
  18. Gao Y, et al. 2022. Cell Res. 32:1086. PubMed
  19. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  20. Liang Y, et al. 2022. Theranostics. 12:7729. PubMed
  21. Cattaneo P, et al. 2022. Nat Commun. 13:7444. PubMed
  22. Wang H, et al. 2022. J Nanobiotechnology. 20:513. PubMed
  23. Kuo CS, et al. 2022. Elife. 11: . PubMed
  24. Ge Y, et al. 2022. STAR Protoc. 4:101936. PubMed
  25. Yu J, et al. 2022. Nat Commun. 13:7903. PubMed
  26. Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed
  27. Al-Saafeen BH, et al. 2023. Front Immunol. 13:1017780. PubMed
  28. Hu R, et al. 2023. Cell Death Discov. 9:50. PubMed
  29. Wang L, et al. 2023. Oxid Med Cell Longev. 2023:6480848. PubMed
  30. Dragan M, et al. 2022. J Invest Dermatol. 142:583. PubMed
  31. Wei J, et al. 2022. Cancer Prev Res (Phila). 15:285. PubMed
  32. Yang Z, et al. 2022. J Nucl Med. 63:1708. PubMed
  33. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  34. Li DD, et al. 2022. Cell Host Microbe. 30:530. PubMed
  35. Bohrer AC, et al. 2022. Cell Rep. 40:111144. PubMed
  36. Yu L, et al. 2022. Cancer Sci. 113:3980. PubMed
  37. Kuo A, et al. 2022. Elife. 11:. PubMed
  38. Chen LC, et al. 2023. Immunology. 169:271. PubMed
  39. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  40. Peng YJ, et al. 2023. Development. 150:. PubMed
  41. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  42. Pioli KT, et al. 2023. iScience. 26:106223. PubMed
  43. Wu Y, et al. 2023. Nat Cancer. 4:382. PubMed
  44. Henn RE, et al. 2023. iScience. 26:106164. PubMed
  45. Barberio AE, et al. 2023. Bioeng Transl Med. 8:e10453. PubMed
  46. Kawai H, et al. 2023. JBMR Plus. 7:e10722. PubMed
  47. Tan X, et al. 2023. Adv Sci (Weinh). 10:e2206768. PubMed
  48. Palakurthi B, et al. 2023. Nat Commun. 14:2109. PubMed
  49. Yao H, et al. 2023. Front Immunol. 14:1147674. PubMed
  50. Hernandez VG, et al. 2023. Glia. 71:1960. PubMed
  51. Liu H, et al. 2023. Breast Cancer Res. 25:43. PubMed
  52. Petenkova A, et al. 2023. Nat Commun. 14:2761. PubMed
  53. Abdelwahab T, et al. 2023. iScience. 26:106698. PubMed
  54. Shao X, et al. 2023. Cell Discov. 9:44. PubMed
  55. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  56. Kalgudde Gopal S, et al. 2023. Nat Commun. 14:3020. PubMed
  57. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  58. Tan L, et al. 2022. Aging Dis. 13:1562. PubMed
  59. Strickley JD, et al. 2019. Nature. 575:519. PubMed
  60. Gavin KM, et al. 2018. Front Endocrinol (Lausanne). 9:276. PubMed
  61. Wang L, et al. 2018. Bone Res. 6:22. PubMed
  62. Cha JH et al. 2018. Molecular cell. 71(4):606-620 . PubMed
  63. Haimon Z et al. 2018. Nature immunology. 19(6):636-644 . PubMed
  64. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  65. Jiang Z, et al. 2021. J Clin Invest. 131: . PubMed
  66. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  67. Shah D, et al. 2021. Oncoimmunology. 10:1939601. PubMed
  68. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  69. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  70. Yang D, et al. 2022. Cell. 185:1905. PubMed
  71. Mourao L, et al. 2019. Sci Rep. 0.991666667. PubMed
  72. Oetjen LK et al. 2017. Cell. 171(1):217-228 . PubMed
  73. Testini C, et al. 2019. EMBO Rep. 20:e47845. PubMed
  74. Gao Q, et al. 2019. J Exp Med. 216:688. PubMed
  75. Shavit Stein E, et al. 2018. Neural Plast. 2018:7692182. PubMed
  76. Bouchareychas L, et al. 2021. iScience. 24(8):102847. PubMed
  77. Almada AE, et al. 2021. Cell Reports. 34(4):108656. PubMed
  78. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  79. Garcia-Fabiani MB, et al. 2020. Methods Enzymol. 632:369. PubMed
  80. Jaiswal AK, et al. 2020. Immunobiology. 225:151956. PubMed
  81. Cayre S, et al. 2020. Development. 147:00:00. PubMed
  82. Díaz NM, et al. 2020. Invest Ophthalmol Vis Sci. 61:37:00. PubMed
  83. Ahmed M, et al. 2016. Development. 143: 1663 - 1673. PubMed
  84. Kang I, et al. 2012. Blood. 119:3295. PubMed
  85. Karlen SJ, et al. 2018. J Neuroinflammation. 15:344. PubMed
  86. Du Q, et al. 2019. Front Microbiol. 10:2050. PubMed
  87. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  88. Lim JT, et al. 2020. Mol Cancer Ther. 1809:19. PubMed
  89. Rosa FF, et al. 2020. Bio Protoc. 10:e3619. PubMed
  90. Wang Y, et al. 2021. J Bone Oncol. 30:100386. PubMed
  91. Lu L, et al. 2022. Sci Rep. 12:931. PubMed
  92. Parhiz H, et al. 2022. J Control Release. 344:50. PubMed
  93. Chiche A, et al. 2016. Oncogene. 10.1038/onc.2016.396. PubMed
  94. Eastman A, et al. 2016. J Immunol . 194: 5999-6010. PubMed
  95. Chen J, et al. 2022. Nat Commun. 13:6759. PubMed
  96. Wang S, et al. 2022. Front Immunol. 13:869061. PubMed
  97. Engelbrecht E, et al. 2020. eLife. 9:e52690.. PubMed
  98. Hays C, et al. 2020. eLife. 8:e48772.. PubMed
  99. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  100. Yu X, et al. 2021. Nature. 594:560. PubMed
  101. Sato S, et al. 2021. Int J Mol Sci. 22:. PubMed
  102. Oliva Chávez AS, et al. 2021. Nat Commun. 12:3696. PubMed
  103. Yanagida K, et al. 2020. Dev Cell. 779:52. PubMed
  104. Hirano KI, et al. 2021. eLife. 0.416666666666667. PubMed
  105. Larouche JA, et al. 2021. eLife. 0.416666666666667. PubMed
  106. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  107. Barberio AE, et al. 2020. ACS Nano. 14:11238. PubMed
  108. Zhang Y, et al. 2022. Cancers (Basel). 14:. PubMed
  109. Barwe SP, et al. 2022. J Clin Med. 11:. PubMed
  110. Tilstam PV, et al. 2021. J Clin Invest. 131:. PubMed
  111. Jin X, et al. 2019. Mol Cell. 73:22:00. PubMed
  112. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  113. Strunz M, et al. 2020. Nat Commun. 2.929861111. PubMed
  114. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  115. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  116. Wosczyna MN, et al. 2021. Cell Stem Cell. 28(7):1323-1334.e8. PubMed
  117. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  118. Zhao B, et al. 2021. Cell Reports. 36(3):109401. PubMed
  119. Motoyama S, et al. 2020. Cells. :9. PubMed
  120. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  121. Romagnoli M, et al. 2020. Development. 147:. PubMed
  122. Li Q, et al. 2021. Brain Behav Immun. 94:437. PubMed
  123. Wang X, et al. 2022. Nat Aging. 2:155. PubMed
  124. Wang T, et al. 2020. Blood Sci. 2:79. PubMed
  125. Liu L, et al. 2015. Neurol Neuroimmunol Neuroinflamm. 2: 174. PubMed
  126. Hyatt L, et al. 2014. PLoS One. 9:109072. PubMed
  127. Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed
  128. Chen Z, et al. 2022. Theranostics. 12:6242. PubMed
  129. Pelletier A, et al. 2012. J Immunol. 188:5561. PubMed
  130. Herting CJ, et al. 2019. Brain. 142:3834. PubMed
  131. Romagnoli M, et al. 2019. Stem Cell Reports. 1.077083333. PubMed
  132. Ning X, et al. 2019. Mol Cell. 74:19. PubMed
  133. De S, et al. 2018. Development. 145. PubMed
  134. Xiao X, et al. 2019. Cell Discov. 5:2. PubMed
  135. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  136. Amouyal C, et al. 2020. EBioMedicine. 58:102895. PubMed
  137. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  138. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  139. Khateb M, et al. 2022. Cell Rep. 40:111219. PubMed
  140. Xu Q, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  141. Liu K, et al. 2022. Theranostics. 12:639. PubMed
  142. Sato Y, et al. 2021. J Clin Invest. Online ahead of print. PubMed
  143. Lafkas D, et al. 2013. J Cell Biol. 203:47. PubMed
  144. Sambasivan R, et al. 2011. Development. 138:3647. PubMed
  145. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  146. Wosczyna MN et al. 2019. Cell Rep. 27(7):2029-2035 . PubMed
  147. Maston LD, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L609. PubMed
  148. Bresson L, et al. 2018. Development. 145. PubMed
  149. Charmsaz S, et al. 2017. Leukemia. 31:1779. PubMed
  150. Ma S, et al. 2021. Cell Reports. 34(6):108726. PubMed
  151. Ankawa R, et al. 2021. Developmental Cell. . PubMed
  152. Hu EY, et al. 2021. Blood Adv. 5:3152. PubMed
  153. Palathingal Bava E, et al. 2022. JCI Insight. 7:. PubMed
  154. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  155. Xiao P, et al. 2019. J Exp Med. 216:337. PubMed
  156. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  157. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  158. Zheng B, et al. 2018. J Hematol Oncol. 11:16. PubMed
  159. Pal B, et al. 2017. Nat Commun.. 10.1038/s41467-017-01560-x. PubMed
  160. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  161. Shcherbina A, et al. 2020. Cell Rep. 32:107964. PubMed
  162. Wu J, et al. 2020. Immunity. 53:115. PubMed
  163. Frii J, et al. 2021. Immunity. 54(5):1002-1021.e10. PubMed
  164. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  165. Fischer A, et al. 2022. Nat Immunol. 23:518. PubMed
  166. Hu J, et al. 2022. Cell Mol Neurobiol. . PubMed
  167. Pezoldt J, et al. 2022. Nat Commun. 13:7227. PubMed
  168. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  169. Yuan Z, et al. 2018. Emerg Microbes Infect. 7:59. PubMed
  170. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  171. Morimoto A, et al. 2021. Nat Commun. 12:2136. PubMed
  172. Hanasoge Somasundara AV, et al. 2021. Cell Rep. 37:110099. PubMed
  173. Thinard R, et al. 2022. Pharmaceutics. 14:. PubMed
  174. Yang H, et al. 2022. Nutrients. 14:. PubMed
  175. Hu J, et al. 2022. J Neuroinflammation. 19:71. PubMed
  176. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  177. Dudek KA, et al. 2020. Proc Natl Acad Sci U S A. 117:3326. PubMed
  178. Bradley KC, et al. 2019. Cell Rep. 28:245. PubMed
  179. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  180. Paiva-Oliveira E, et al. 2017. Histochem Cell Biol. 10.1007/s00418-017-1556-6. PubMed
  181. Yang J, et al. 2022. Microbiome. 10:149. PubMed
  182. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  183. Koren E, et al. 2022. Nat Commun. 13:4628. PubMed
  184. Bauer T, et al. 2021. Life (Basel). 11:. PubMed
  185. Li P, et al. 2022. EMBO Mol Med. 14:e14511. PubMed
  186. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  187. Myerson JW, et al. 2021. Nat Nanotechnol. Online ahead of print. PubMed
  188. Wang C, et al. 2011. Hepatology. 55:108. PubMed
  189. Sim S, et al. 2016. PLoS One. 11: 0152485. PubMed
  190. Mangum L, et al. 2016. Toxicol Sci. 150: 169 - 177. PubMed
  191. Scur M, et al. 2022. Nat Commun. 13:7272. PubMed
  192. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  193. Liu S, et al. 2020. Cell Host & Microbe. 26(6):779-794.e8.. PubMed
  194. Zhou G, et al. 2019. FASEB J. 33:11396. PubMed
  195. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  196. Nosho S, et al. 2020. Int J Mol Sci. 21:00. PubMed
  197. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  198. Shannon JP, et al. 2021. STAR Protoc. 2:100790. PubMed
  199. Yang Y, et al. 2022. Elife. 11:. PubMed
  200. Dey S, et al. 2020. J Immunother Cancer. 8:. PubMed
  201. Zhang Q, et al. 2022. Nat Commun. 13:2406. PubMed
  202. Seki T, et al. 2015. J Biochem. 158: 485 - 495. PubMed
  203. Yamada KJ, et al. 2020. PLoS Pathog. 16:e1008354. PubMed
  204. Tu WL, et al. 2018. Am J Pathol. 188:2688. PubMed
  205. Chiche A, et al. 2019. Breast Cancer Res. 21:13. PubMed
  206. Feng J,et al. 2017. Nat Commun. . 10.1038/s41467-017-01056-8. PubMed
  207. Xi W, et al. 2021. Stem Cell Res Ther. 167:12. PubMed
  208. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  209. Dawson CA, et al. 2021. Nature Protocols. 16(4):1907-1935. PubMed
  210. Limbad C, et al. 2022. iScience. 25:103848. PubMed
  211. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  212. Aguilera M, et al. 2021. Int J Mol Sci. 22:. PubMed
  213. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  214. Ding X, et al. 2015. J Immunol. 194:4251. PubMed
  215. Wang L, et al. 2015. Cancer Immunol Res. 3: 1030-1041. PubMed
  216. Mueller A, et al. 2016. Nature. 540:276-279. PubMed
  217. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  218. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  219. Liu D, et al. 2020. Front Pharmacol. 11:204. PubMed
  220. Echevarría-Vargas IM, et al. 2018. EMBO Mol Med. 10:e8446. PubMed
  221. Shi R, et al. 2019. J Cancer. 10:367. PubMed
  222. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  223. Usmani SM et al. 2019. Cell host & microbe. 25(1):73-86 . PubMed
  224. Zasłona Z, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L855. PubMed
  225. Perry JL, et al. 2020. ACS Nano. 5.583333333. PubMed
  226. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  227. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  228. Mori A, et al. 2021. Cells. :10. PubMed
  229. Dion-Albert L, et al. 2022. Nat Commun. 13:164. PubMed
  230. Long JT, et al. 2022. Elife. 11:. PubMed
  231. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  232. Cai B, et al. 2020. Cell Metabolism. 31(2):406-421.e7.. PubMed
  233. Lu Y, et al. 2020. Immunity. 52:782. PubMed
  234. Toyama K, et al. 2018. Arterioscler Thromb Vasc Biol. 38:1392. PubMed
  235. Qiao S, et al. 2019. J Neuroinflammation. 16:4. PubMed
  236. Murdock BJ, et al. 2021. JCI Insight. 6:. PubMed
  237. Yang Y, et al. 2021. Cell Reports. 34(10):108822. PubMed
  238. Taya M, et al. 2020. Endocr Relat Cancer. 27:261. PubMed
  239. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  240. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  241. Elias S, et al. 2015. PLoS Biol. 13:1002142. PubMed
  242. Hoover AR, et al. 2022. Clin Transl Med. 12:e937. PubMed
  243. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  244. Yeo SK, et al. 2020. eLife. 9:e58810.. PubMed
  245. Carmody C et al. 2019. Endocrinology. 160(5):1205-1222 . PubMed
  246. Fu NY, et al. 2018. Dev Cell. 47:629. PubMed
  247. Deng P, et al. 2021. Cell Stem Cell. 28(6):1057-1073.e7. PubMed
  248. Zhang Y, et al. 2020. Cancer Res. 80:3345. PubMed
  249. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  250. Nasser H, et al. 2020. Cell Death Discov. 0.29375. PubMed
  251. Sroor HM, et al. 2019. Sci Rep. 9:20217. PubMed
  252. Chen PY, et al. 2019. Nat Metab. 0.675. PubMed
  253. Cao Y, et al. 2019. Nat Commun. 10:1280. PubMed
  254. Liu L et al. 2018. Cell stem cell. 23(4):544-556 . PubMed
  255. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  256. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  257. Kim KS, et al. 2022. JCI Insight. 7:. PubMed
  258. Porrello A, et al. 2018. Nat Commun. 9:1988. PubMed
  259. Zhang T, et al. 2020. JCI Insight. 5:00. PubMed
  260. Cai T, et al. 2022. Nat Commun. 13:2228. PubMed
  261. Vaas M, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16676825. PubMed
  262. Wong J, et al. 2016. Sci Signal. 9: ra103. PubMed
  263. Yuan Z, et al. 2016. J Virol. 90: 7728 - 7739. PubMed
  264. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  265. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  266. Roberts L, et al. 2014. Infect Immun . 82:2504. PubMed
  267. Gopalakrishnapillai A, et al. 2021. Cancers (Basel). 13:. PubMed
  268. Ortiz A, et al. 2019. Cancer Cell. 35:33:00. PubMed
  269. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  270. Piotrowski AF, et al. 2018. Oncoimmunology. 7:e1445951. PubMed
  271. Sarshad AA, et al. 2018. Mol Cell. 71:1040. PubMed
  272. Pal B, et al. 2021. Breast Cancer Res. 23:69. PubMed
  273. Maller O, et al. 2020. Nat Mater. 20:548. PubMed
  274. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  275. Liu G, et al. 2022. Theranostics. 12:2248. PubMed
  276. Piirainen S, et al. 2021. Glia. 69:2459. PubMed
  277. Arora S, et al. 2021. Med (N Y). 2:938. PubMed
  278. Li H, et al. 2022. iScience. 25:104481. PubMed
  279. Cayre S, et al. 2020. Development. . PubMed
  280. Endo-Umeda K, et al. 2021. Sci Rep. 11:22595. PubMed
  281. Qu Y, et al. 2020. Cell Reports. 32(1):107873. PubMed
  282. Su M, et al. 2018. Immunol Cell Biol. 9:2448. PubMed
  283. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  284. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  285. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  286. Koh BI, et al. 2020. Nat Commun. 3.143055556. PubMed
  287. Ren D, et al. 2020. Am J Cancer Res. 2851:10. PubMed
  288. Hu Y, et al. 2021. J Nanobiotechnology. 19:416. PubMed
  289. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  290. Chng S, et al. 2016. Sci Rep. 6: 23820. PubMed
  291. Quijano-Rubio A, et al. 2022. Nat Biotechnol. Online ahead of print. PubMed
  292. Scheyltjens I, et al. 2022. Nat Protoc. 17:2354. PubMed
  293. Kabir AU, et al. 2018. JCI Insight. 3. PubMed
  294. Xie Z, et al. 2020. Light Sci Appl. 9:161. PubMed
  295. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  296. Bravo JI, et al. 2021. STAR Protocols. 2(2):100406. PubMed
  297. Liu C, et al. 2022. Nat Commun. 13:1989. PubMed
  298. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  299. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  300. Okubo A, et al. 2021. Int J Mol Sci. 23:. PubMed
  301. Deets KA, et al. 2021. Elife. 10:. PubMed
  302. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  303. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  304. Zhong J, et al. 2021. Commun Biol. 4:865. PubMed
RRID
AB_312976 (BioLegend Cat. No. 103111)
AB_312977 (BioLegend Cat. No. 103112)

Antigen Details

Structure
Protein tyrosine phosphatase (PTP) family, 180-240 kD
Distribution

All hematopoietic cells except mature erythrocytes and platelets

Function
Phosphatase, T and B cell activation
Ligand/Receptor
Galectin-1, CD2, CD3, CD4, TCR, CD22, Thy-1
Cell Type
B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Trowbridge IS, et al. 1993. Annu. Rev. Immunol. 12:85.
3. Kishihara K, et al. 1993. Cell 74:143.
4. Pulido R, et al. 1988. J. Immunol. 140:3851.

Gene ID
19264 View all products for this Gene ID
UniProt
View information about CD45 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD45 Reagents Request Custom Conjugation
Description Clone Applications
PE anti-mouse CD45 30-F11 FC
PE/Cyanine5 anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 30-F11 FC,IHC-F,CyTOF®,IP,CMCD,IHC,WB
PE/Cyanine7 anti-mouse CD45 30-F11 FC
PE/Dazzle™ 594 anti-mouse CD45 30-F11 FC
Brilliant Violet 711™ anti-mouse CD45 30-F11 FC
Brilliant Violet 785™ anti-mouse CD45 30-F11 FC
Brilliant Violet 650™ anti-mouse CD45 30-F11 FC
APC/Fire™ 750 anti-mouse CD45 30-F11 FC
Brilliant Violet 750™ anti-mouse CD45 30-F11 FC
TotalSeq™-A0096 anti-mouse CD45 30-F11 PG
TotalSeq™-B0096 anti-mouse CD45 30-F11 PG
Ultra-LEAF™ Purified anti-mouse CD45 30-F11 FC,CyTOF®,IP,CMCD,IHC,WB
Spark Blue™ 550 anti-mouse CD45 30-F11 FC
Spark NIR™ 685 anti-mouse CD45 30-F11 FC
TotalSeq™-C0096 anti-mouse CD45 30-F11 PG
Spark YG™ 570 anti-mouse CD45 30-F11 IHC-F
PE/Fire™ 640 anti-mouse CD45 30-F11 FC
APC/Fire™ 810 anti-mouse CD45 30-F11 FC
PE/Fire™ 700 anti-mouse CD45 30-F11 FC
APC anti-mouse CD45 30-F11 FC
Biotin anti-mouse CD45 30-F11 FC
FITC anti-mouse CD45 30-F11 FC
APC/Cyanine7 anti-mouse CD45 30-F11 FC
Alexa Fluor® 488 anti-mouse CD45 30-F11 FC,SB
Alexa Fluor® 647 anti-mouse CD45 30-F11 FC,ICC,IHC,3D IHC,SB
Pacific Blue™ anti-mouse CD45 30-F11 FC
Alexa Fluor® 700 anti-mouse CD45 30-F11 FC,SB
PerCP/Cyanine5.5 anti-mouse CD45 30-F11 FC
PerCP anti-mouse CD45 30-F11 FC
Alexa Fluor® 594 anti-mouse CD45 30-F11 IHC-F,FC,3D IHC
Brilliant Violet 421™ anti-mouse CD45 30-F11 FC,SB
Brilliant Violet 570™ anti-mouse CD45 30-F11 FC
Brilliant Violet 510™ anti-mouse CD45 30-F11 FC
Brilliant Violet 605™ anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 (Maxpar® Ready) 30-F11 FC,CyTOF®
Spark Violet™ 538 anti-mouse CD45 30-F11 FC
Spark YG™ 593 anti-mouse CD45 30-F11 FC
Spark Blue™ 574 anti-mouse CD45 Antibody 30-F11 FC
Spark Blue™ 515 anti-mouse CD45 30-F11 FC
Spark UV™ 387 anti-mouse CD45 30-F11 FC
PE/Fire™ 810 anti-mouse CD45 30-F11 FC
Spark PLUS UV395™ anti-mouse CD45 30-F11 FC
Spark Red™ 718 anti-mouse CD45 30-F11 FC
Spark YG™ 581 anti-mouse CD45 (Flexi-Fluor™) 30-F11 FC
StarBright UltraViolet 740 anti-mouse CD45 30-F11 FC
PE/Fire™ 744 anti-mouse CD45 30-F11 FC
Spark PLUS V475™ anti-mouse CD45 Antibody 30-F11 FC
Go To Top Version: 2    Revision Date: 05/14/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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